T-cell therapy offers cancer cure

Rare white blood cells in the immune system known as T-cells could be programmed to stop cancers forming. Dubbed a “living drug” treatment, T-cells would seek and destroy cancerous tumour cells

How T-cell therapy works

T-cells: Cannot recognize cancer cells as foreign intruders as they can with other forms of infection. Cells need to be “specially trained”

T-cells are extracted from patient’s blood

1

Plasma (55%)

White blood cells and platelets (<1%)

Receptors

Red blood cells (44%)

T-cell engineering: Synthetic genes are inserted into T-cell DNA. Genes enable receptors projecting from cell wall to identify protein called CD19

2

Engineered T-cells are returned to patient intravenously. Receptors activate
T-cells, instructing them to attack cancerous cells that contain CD19

3

T-cell replicates itself and recruits other parts of immune system to fight cancer

Cancer cell

Sources: AAAS, Vita-Salute San Raffaele University

T-cell therapy offers cancer cure

Rare white blood cells in the immune system known as T-cells could be programmed to stop cancers forming. Dubbed a “living drug” treatment, T-cells would seek and destroy cancerous tumour cells

How T-cell therapy works

T-cells are extracted from patient’s blood

1

Receptors

Plasma (55%)

White blood cells and platelets (<1%)

Red blood cells (44%)

T-cells: Cannot recognize cancer cells as foreign intruders as they can with other forms of infection. Cells need to be “specially trained”

T-cell engineering: Synthetic genes are inserted into T-cell DNA. Genes enable receptors projecting from cell wall to identify protein called CD19

2

Engineered T-cells are returned to patient intravenously. Receptors activate T-cells, instructing them to attack cancerous cells that contain CD19

3

Cancer cell

T-cell replicates itself and recruits other parts of immune system to fight cancer

Sources: AAAS, Vita-Salute San Raffaele University

T-cell therapy offers cancer cure

Rare white blood cells in the immune system known as
T-cells could be programmed to stop cancers forming. Dubbed a “living drug” treatment, T-cells would seek and destroy cancerous tumour cells

How T-cell therapy works

T-cells are extracted from patient’s blood

1

Plasma (55%)

White blood cells and platelets (<1%)

Red blood cells (44%)

T-cells: Cannot recognize cancer cells as foreign intruders as they can with other forms of infection. Cells need to be “specially trained”

Receptors

T-cell engineering: Synthetic genes are inserted into T-cell DNA. Genes enable receptors projecting from cell wall to identify protein called CD19

2

Engineered T-cells are returned to patient intravenously. Receptors activate T-cells, instructing them to attack cancerous cells that contain CD19

3

Cancer cell

T-cell replicates itself and recruits other parts of immune system to fight cancer

Sources: AAAS, Vita-Salute San Raffaele University