U.S. fentanyl overdose deaths soar Fentanyl, a powerful synthetic opioid vastly more potent than morphine, is linked to two-thirds of all drug overdose deaths in the United States, as a “fourth wave” grips the nation OVERDOSE MORTALITY (deaths per 100,000 people) OVERDOSE DEATHS WITH OR WITHOUT FENTANYL (% share) 2021 2011 16 78 Overdose with no fentanyl or stimulants 18 16 Stimulants without fentanyl 32 Fentanyl with stimulants 34 6 Fentanyl without stimulants Fentanyl can be swallowed, snorted or injected 11 10 9 8 7 6 5 4 3 2 1 0 2000 2002 2004 2006 2008 2010 2012 2014 2016 2018 2020 WAVE 1 2000: Rise in prescribed opioids WAVE 2 2010: Rise in heroin without stimulants WAVE 3 2013: Rise in fentanyl without stimulants WAVE 4 2015: Rise in fentanyl with stimulants Increase in fentanyl deaths attributed to drug being mixed with other stimulants like cocaine or methamphetamine, to produce longer highs Sources: BBC, Wiley Online Library Picture: Diana Polekhina (Unsplash) © GRAPHIC NEWS