Deadly fentanyl surge in U.S. Drug overdoses took the lives of more than 107,500 Americans in the 12 months to June 2022, with the synthetic opioid fentanyl playing a role in almost nine in 10 of these deaths Deaths from synthetic opioids (mostly fentanyl, % of total) Other overdose deaths (12 months to June) 2016-17 43,834 24,911 68,745 36.2% 2017-18 38,295 29,961 68,256 43.9% 2018-19 34,918 32,392 67,310 48.1% 2019-20 34,774 46,966 81,740 57.5% 2020-21 36,384 71,238 66.2% 107,622 2021-22 12,910 94,672 88.0% 107,582 Mar 2020 Covid lockdown Source: Centers for Disease Control and Prevention Picture: Getty Images © GRAPHIC NEWS