Covid “breakthrough” cases explained Most hospitalisations and deaths from coronavirus have occurred among unvaccinated individuals, yet there have also been so-called breakthrough infections of fully vaccinated people Why breakthrough cases occur No vaccine is 100 percent effective at preventing infection in all cases. As more people have become vaccinated against Covid-19, so number of breakthrough cases has increased Natural virus evolution SARS-CoV-2 continues to mutate into variants that are more infectious and more adept at evading immunity provided by vaccination or previous Covid-19 infection Vaccine effectiveness Research shows most vaccines are working to dramatically decrease risk of hospitalisation and death, even against highly-transmissible Delta variant. For example, Pfizer vaccine is 96 percent effective against hospitalisation from Delta variant after two doses Individual immune response Chances of getting seriously ill after vaccination are higher for those people with health conditions that affect immune system. Even in those with good immunity, vaccine protection is likely to wane over time Severity of illness Infections among vaccinated people tend to be mild, with fewer symptoms. Severe cases are extremely rare As of July 12, out of 159 million fully vaccinated people, CDC* recorded 5,492 cases who were hospitalised or died from Covid-19 (equivalent to less than 1 in 29,000) Share of cases aged 65 or over 75% 19 percent of total cases died *Centres for Disease Control and Prevention Sources: Bloomberg, CDC, NPR Picture: Getty Images © GRAPHIC NEWS