How mRNA vaccines work ------------------------------ Messenger RNA vaccines carry genetic instructions which enable a recipient’s cells to make proteins that prime the immune system ------------------------------ Coronavirus “Spike” protein ------------------------------ 1. RNA vaccine: Messenger RNA (mRNA) is made from DNA template – mRNA contains sequence that codes for virus spike protein Synthetic mRNA sequence DNA template ------------------------------ 2. RNA sequence: Blueprint for making spike protein is packaged in microscopic oily-lipid droplets for delivery mRNA lipid nanoparticles ------------------------------ 3. Vaccination: Recipient cells read mRNA sequence and produce millions of copies of spike protein Human cell Antibodies Protein T cells ------------------------------ 4. Viral protein: Displayed on surface of cell, it stimulates immune system to produce antibodies ------------------------------ 5. If enough antibodies bind to virus, it can not enter cells to make copies of itself ------------------------------ Sources: Pfizer, Moderna, Bloomberg, Reuters © GRAPHIC NEWS