Surge in U.S. opioid deaths The largest civil trial in American history will take place in Cleveland, Ohio, to determine responsibility for an opioid epidemic which has led to almost 400,000 deaths over the past 19 years Defendants: Include “Big Three” pharmaceutical companies which allegedly distributed more than 80% of drugs at issue All opioid deaths between 1999 and 2017 399,212 Prescription opioid deaths 217,530 2009: One in eight Americans uses opioid analgesics 2017: 28,466 deaths involving synthetic opioids Opioid deaths (thousands, annual) All opioids Prescription opioids 47,600 40 33,091 30 20,442. 25,050 20 13,523 14,145 15,281 17,029 10 8,048 0 3,442 99 00 01 02 03 04 05 06 07 08 09 10 11 12 13 14 15 16 17 Sources: National Center on Health Statistics, CDC Picture: Associated Press © GRAPHIC NEWS